Multiple boli arterial spin labelling for high signal-to-noise rodent brain perfusion imaging

Holmes, W. M. , Vallatos, A. , Gilmour, L. and Chalmers, A. J. (2018) Multiple boli arterial spin labelling for high signal-to-noise rodent brain perfusion imaging. Magnetic Resonance in Medicine, 79(2), pp. 1020-1030. (doi: 10.1002/mrm.26706) (PMID:28516482)

138662.pdf - Accepted Version



Purpose: A systematic method is proposed for optimizing a promising preclinical arterial spin labeling (ASL) sequence based on the use of a train of adiabatic radiofrequency pulses labeling successive boli of blood water. Methods: The sequence optimization is performed and evaluated using brain imaging experiments in mice and in rats. It involves the investigation of several parameters, ranging from the number of adiabatic pulses and labeling duration to the properties of the adiabatic hyperbolic secant pulses (ie, amplitude and frequency modulation). Results: Species-dependent parameters are identified, allowing for robust fast optimization protocols to be introduced. The resulting optimized multiple boli ASL (mbASL) sequence provides with significantly higher average signal-to-noise ratios (SNR) per voxel volume than currently encountered in ASL studies (278 mm−3 in mice and 172 mm−3 in rats). Comparing with the commonly used flow-sensitive alternating inversion recovery technique (FAIR), mbASL-to-FAIR SNR ratios reach 203% for mice and 725% for rats. Conclusion: When properly optimized, mbASL can offer a robust, high SNR ASL alternative for rodent brain perfusion studies.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Chalmers, Professor Anthony and Gilmour, Dr Lesley and Vallatos, Dr Antoine and Holmes, Dr William
Authors: Holmes, W. M., Vallatos, A., Gilmour, L., and Chalmers, A. J.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Magnetic Resonance in Medicine
ISSN (Online):1522-2594
Published Online:17 May 2017
Copyright Holders:Copyright © 2017 International Society for Magnetic Resonance in Medicine
First Published:First published in Magnetic Resonance in Medicine 79(2): 1020-1030
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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