Chromosome organisation during ageing and senescence

Chandra, T. and Kirschner, K. (2016) Chromosome organisation during ageing and senescence. Current Opinion in Cell Biology, 40, pp. 161-167. (doi: 10.1016/ (PMID:27101466)

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Acute cellular stress caused by oncogene activation or high levels of DNA damage can engage a tumour suppressive response, which can lead to cellular senescence. Chronic cellular stress evoked by low levels of DNA damage or telomere erosion is involved in the ageing process. In oncogene induced senescence in fibroblasts, a dramatic rearrangement of heterochromatin into foci and accumulation of constitutive heterochromatin is well documented. In contrast, a loss of heterochromatin has been described in replicative senescence and premature ageing syndromes. The distinct nuclear phenotypes that accompany the stress response highlight the differences between acute and chronic stress models, and this review will address the differences and similarities between these models with a focus on chromosome organisation and heterochromatin.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Kirschner, Dr Kristina
Authors: Chandra, T., and Kirschner, K.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Current Opinion in Cell Biology
ISSN (Online):1879-0410
Published Online:19 April 2016
Copyright Holders:Copyright © 2016 Elsevier Ltd.
First Published:First published in Current Opinion in Cell Biology 40: 161-167
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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