Vaccine immune pressure influences viral population complexity of avian influenza virus during infection

Milani, A. et al. (2017) Vaccine immune pressure influences viral population complexity of avian influenza virus during infection. Veterinary Microbiology, 203, pp. 88-94. (doi:10.1016/j.vetmic.2017.02.016)

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Abstract

Vaccines are useful tools to control influenza A virus infection in poultry, but they need to be periodically reformulated to guarantee appropriate protection from infection and to limit viral replication and circulation, which could favour the emergence of new variants. In this study, a deep sequencing approach was used to characterize and follow the evolution of the hemagglutinin of the H5N1 highly pathogenic avian influenza viral population in infected animals vaccinated with two vaccines conferring different protection levels. Results from this preliminary investigation suggested that the evolution of the viral population, as well as the abundance and heterogeneity of minority variants could be influenced by the immune pressure conferred by vaccination.

Item Type:Articles
Additional Information:This work was financially supported by the European projects Epi-SEQ (research project supported under the 2nd Joint Call for Transnational Research Projects by EMIDA ERA-NET [FP7 project no. 219235]), by the NoFlu project, Fondazione Cariplo Vaccine Program (grant number 2009-3594) and by Boehringer Ingelheim Vetmedica.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hughes, Dr Joseph
Authors: Milani, A., Fusaro, A., Bonfante, F., Zamperin, G., Salviato, A., Mancin, M., Mastrorilli, E., Hughes, J., Hussein, H. A., Hassan, M., Mundt, E., Terregino, C., Cattoli, G., and Monne, I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Veterinary Microbiology
Publisher:Elsevier
ISSN:0378-1135
ISSN (Online):1873-2542
Published Online:27 February 2017
Copyright Holders:Copyright © 2017 Elsevier B.V.
First Published:First published in Veterinary Microbiology 203: 88-94
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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