Reynolds, L. A. et al. (2017) Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome. Journal of Infectious Diseases, 215(8), pp. 1245-1254. (doi: 10.1093/infdis/jix141) (PMID:28368463)
|
Text
138435.pdf - Accepted Version 1MB |
Abstract
Intestinal helminth infections occur pre dominantly in regions where exposure to enteric bacterial pathogens is also common. Helminth infections inhibit host immunity against microbial pathogens, which has largely been attributed to the induction of regulatory or type 2 (Th2) immune responses. Here we demonstrate an additional three-way interaction in which helminth infection alters the metabolic environment of the host intestine to enhance bacterial pathogenicity. We show that an ongoing helminth infection increased colonization by Salmonella independently of T regulatory or Th2 cells. Instead, helminth infection altered the metabolic profile of the intestine, which directly enhanced bacterial expression of Salmonella pathogenicity island 1 (SPI-1) genes and increased intracellular invasion. These data reveal a novel mechanism by which a helminth-modified metabolome promotes susceptibility to bacterial co-infection.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Perona-Wright, Dr Georgia |
Authors: | Reynolds, L. A., Redpath, S. A., Yurist-Doutsch, S., Gill, N., Brown, E. M., van der Heijden, J., Brosschot, T. P., Han, J., Marshall, N. C., Woodward, S. E., Valdez, Y., Borchers, C. H., Perona-Wright, G., and Finlay, B. B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Infectious Diseases |
Publisher: | Infectious Diseases Society of America |
ISSN: | 0022-1899 |
ISSN (Online): | 1537-6613 |
Published Online: | 25 March 2017 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Journal of Infectious Diseases 215(8): 1245-1254 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
University Staff: Request a correction | Enlighten Editors: Update this record