Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome

Reynolds, L. A. et al. (2017) Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome. Journal of Infectious Diseases, 215(8), pp. 1245-1254. (doi: 10.1093/infdis/jix141) (PMID:28368463)

138435.pdf - Accepted Version



Intestinal helminth infections occur pre dominantly in regions where exposure to enteric bacterial pathogens is also common. Helminth infections inhibit host immunity against microbial pathogens, which has largely been attributed to the induction of regulatory or type 2 (Th2) immune responses. Here we demonstrate an additional three-way interaction in which helminth infection alters the metabolic environment of the host intestine to enhance bacterial pathogenicity. We show that an ongoing helminth infection increased colonization by Salmonella independently of T regulatory or Th2 cells. Instead, helminth infection altered the metabolic profile of the intestine, which directly enhanced bacterial expression of Salmonella pathogenicity island 1 (SPI-1) genes and increased intracellular invasion. These data reveal a novel mechanism by which a helminth-modified metabolome promotes susceptibility to bacterial co-infection.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Perona-Wright, Dr Georgia
Authors: Reynolds, L. A., Redpath, S. A., Yurist-Doutsch, S., Gill, N., Brown, E. M., van der Heijden, J., Brosschot, T. P., Han, J., Marshall, N. C., Woodward, S. E., Valdez, Y., Borchers, C. H., Perona-Wright, G., and Finlay, B. B.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Infectious Diseases
Publisher:Infectious Diseases Society of America
ISSN (Online):1537-6613
Published Online:25 March 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Journal of Infectious Diseases 215(8): 1245-1254
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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