Is chronic obstructive pulmonary disease associated with increased arterial stiffness?

Janner, J. H., McAllister, D. A. , Godtfredsen, N. S., Prescott, E. and Vestbo, J. (2012) Is chronic obstructive pulmonary disease associated with increased arterial stiffness? Respiratory Medicine, 106(3), pp. 397-405. (doi: 10.1016/j.rmed.2011.08.016) (PMID:22136986)

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Abstract

Objective: We hypothesize that airflow limitation is associated with increasing arterial stiffness and that having COPD increases a non-invasive measure of arterial stiffness – the aortic augmentation index (AIx) – independently of other CVD risk factors. Methods: This population study is based on 3374 subjects from the Copenhagen City Heart Study; 494 had COPD. We used multiple linear regression analyses to examine the association between COPD and AIx adjusted for CVD risk factors. Furthermore, we analyzed the association between AIx and FEV1, FVC and FEV1/FVC in the entire population. Results: AIx was higher in subjects with COPD than in subjects without: 25.7 vs. 21.0 (p < 0.001) in men and 33.6 vs. 29.4 (p < 0.001) in women. We found no increase in AIx with COPD adjusted for CVD risk factors: difference 0.63 (−0.26 to 1.52, p = 0.16). In sensitivity analyses in subjects younger than 60 years with exclusion of mild COPD from the analyses, COPD was associated with an increase in AIx in men only of 4.1 (0.88–7.22, p = 0.007). AIx had a curvilinear association with FEV1 and FVC but no association with the FEV1/FVC ratio. Conclusion: AIx and COPD are only weakly associated. In the general population, this finding argues against increased arterial stiffness, as measured by AIx, being a complication of COPD.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McAllister, Professor David
Authors: Janner, J. H., McAllister, D. A., Godtfredsen, N. S., Prescott, E., and Vestbo, J.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
Journal Name:Respiratory Medicine
Publisher:Elsevier
ISSN:0954-6111
ISSN (Online):1532-3064
Published Online:03 December 2011

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