Romme, E. A.P.M., McAllister, D. A. , Murchison, J. T., Van Beek, E. J.R., Petrides, G. S., Price, C. O.S., Rutten, E. P.A., Smeenk, F. W.J.M., Wouters, E. F.M. and MacNee, W. (2013) Associations between COPD related manifestations: a cross-sectional study. Respiratory Research, 14(1), 129. (doi: 10.1186/1465-9921-14-129) (PMID:24251912) (PMCID:PMC3840707)
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Abstract
Background: Cardiovascular disease, osteoporosis and emphysema are associated with COPD. Associations between these factors and whether they predict all-cause mortality in COPD patients are not well understood. Therefore, we examined associations between markers of cardiovascular disease (coronary artery calcification [CAC], thoracic aortic calcification [TAC] and arterial stiffness), bone density (bone attenuation of the thoracic vertebrae), emphysema (PI-950 and 15th percentile) and all-cause mortality in a COPD cohort. Methods: We assessed CAC, TAC, bone attenuation of the thoracic vertebrae, PI-950 and 15th percentile on low-dose chest computed tomography in COPD subjects. We measured arterial stiffness as carotid-radial pulse wave velocity (PWV), and identified deaths from the national register. Results: We studied 119 COPD subjects; aged 67.8 ±7.3, 66% were males and mean FEV1% predicted was 46.0 ±17.5. Subjects were classified into three pre-specificed groups: CAC = 0 (n = 14), 0 < CAC ≤ 400 (n = 41) and CAC > 400 (n = 64). Subjects with higher CAC were more likely to be older (p < 0.001) and male (p = 0.03), and more likely to have higher systolic blood pressure (p = 0.001) and a history of hypertension (p = 0.002) or ischemic heart disease (p = 0.003). Higher CAC was associated with higher PWV (OR 1.62, p = 0.04) and lower bone attenuation (OR 0.32, p = 0.02), but not with 15th percentile, after adjustment for age, sex and pack-years of smoking. In a Cox proportional hazards model, CAC, TAC and 15th percentile predicted all-cause mortality (HR 2.01, 2.09 and 0.66, respectively). Conclusions: Increased CAC was associated with increased arterial stiffness and lower bone density in a COPD cohort. In addition, CAC, TAC and extent of emphysema predicted all-cause mortality.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McAllister, Professor David |
Authors: | Romme, E. A.P.M., McAllister, D. A., Murchison, J. T., Van Beek, E. J.R., Petrides, G. S., Price, C. O.S., Rutten, E. P.A., Smeenk, F. W.J.M., Wouters, E. F.M., and MacNee, W. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | Respiratory Research |
Publisher: | BioMed Central |
ISSN: | 1465-9921 |
ISSN (Online): | 1465-993X |
Copyright Holders: | Copyright © 2013 Romme et al. |
First Published: | First published in Respiratory Research 14(1):129 |
Publisher Policy: | Reproduced under a Creative Commons License |
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