Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses

Cumberworth, S., Clark, J. J., Kohl, A. and Donald, C. L. (2017) Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses. Cellular Microbiology, 19(5), e12737. (doi: 10.1111/cmi.12737) (PMID:28273394) (PMCID:PMC5413821)

Abstract

The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. Given the lack of antivirals or prophylactic treatments for many flaviviral infections, it is important to fully understand how these viruses affect cellular processes to influence pathogenesis and disease outcome. This review will discuss the strategies mosquito-borne flaviviruses have evolved to antagonise type I interferon mediated immune responses.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Donald, Dr Claire and Clark, Mr Jordan and Kohl, Professor Alain and Cumberworth, Miss Stephanie
• Authors: Cumberworth, S., Clark, J. J., Kohl, A., and Donald, C. L.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Cellular Microbiology
• Publisher: Wiley
• ISSN: 1462-5814
• ISSN (Online): 1462-5822
• Published Online: 22 March 2017
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in Cellular Microbiology 19(5): e12737
• Publisher Policy: Reproduced under a Creative Commons license

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
65655	1	Arbovirus interactions with arthropod hosts	Alain Kohl	Medical Research Council (MRC)	MC_UU_12014/8	MVLS III - CENTRE FOR VIRUS RESEARCH
70868	1	The emergence of Zika virus in Brazil: investigating prevalence and host responses to design preventive strategies	Alain Kohl	Medical Research Council (MRC)	MR/N017552/1	MVLS III - CENTRE FOR VIRUS RESEARCH