Regulation of the adaptive immune response by the IκB family protein Bcl-3

Herrington, F. D. and Nibbs, R. J.B. (2016) Regulation of the adaptive immune response by the IκB family protein Bcl-3. Cells, 5(2), 14. (doi: 10.3390/cells5020014) (PMID:27023613) (PMCID:PMC4931663)

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Bcl-3 is a member of the IκB family of proteins and an important regulator of Nuclear Factor (NF)-κB activity. The ability of Bcl-3 to bind and regulate specific NF-κB dimers has been studied in great depth, but its physiological roles in vivo are still not fully understood. It is, however, becoming clear that Bcl-3 is essential for the proper development, survival and activity of adaptive immune cells. Bcl-3 dysregulation can be observed in a number of autoimmune pathologies, and Bcl3-deficient animals are more susceptible to bacterial and parasitic infection. This review will describe our current understanding of the roles played by Bcl-3 in the development and regulation of the adaptive immune response, including lymphoid organogenesis, immune tolerance, lymphocyte function and dendritic cell biology.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Herrington, Dr Felicity and Nibbs, Professor Rob
Authors: Herrington, F. D., and Nibbs, R. J.B.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Cells
ISSN (Online):2073-4409
Published Online:24 March 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Cells 5(2): 14
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
659831Dissecting the function of Bcl-3 in NF-kappaB signaling in B cellsRuaidhri CarmodyBiotechnology and Biological Sciences Research Council (BBSRC)BB/M003671/1RI INFECTION IMMUNITY & INFLAMMATION