Herrington, F. D. and Nibbs, R. J.B. (2016) Regulation of the adaptive immune response by the IκB family protein Bcl-3. Cells, 5(2), 14. (doi: 10.3390/cells5020014) (PMID:27023613) (PMCID:PMC4931663)
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Abstract
Bcl-3 is a member of the IκB family of proteins and an important regulator of Nuclear Factor (NF)-κB activity. The ability of Bcl-3 to bind and regulate specific NF-κB dimers has been studied in great depth, but its physiological roles in vivo are still not fully understood. It is, however, becoming clear that Bcl-3 is essential for the proper development, survival and activity of adaptive immune cells. Bcl-3 dysregulation can be observed in a number of autoimmune pathologies, and Bcl3-deficient animals are more susceptible to bacterial and parasitic infection. This review will describe our current understanding of the roles played by Bcl-3 in the development and regulation of the adaptive immune response, including lymphoid organogenesis, immune tolerance, lymphocyte function and dendritic cell biology.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Herrington, Dr Felicity and Nibbs, Professor Rob |
| Authors: | Herrington, F. D., and Nibbs, R. J.B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Cells |
| Publisher: | MDPI |
| ISSN: | 2073-4409 |
| ISSN (Online): | 2073-4409 |
| Published Online: | 24 March 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Cells 5(2): 14 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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