Sinkins, S. P. and Hastings, I. M. (2004) Male-specific insecticide resistance and mosquito transgene dispersal. Trends in Parasitology, 20(9), pp. 413-416. (doi: 10.1016/j.pt.2004.07.003) (PMID:15324731)
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Abstract
There is a need to develop methods to spread disease-blocking transgenes through mosquito populations. This article discusses the possibility of linking transgenes to insecticide-resistant alleles engineered to be expressed only in males. The resulting increase in mean longevity of males carrying the construct under insecticide treatment could easily outweigh any fitness costs in females, so that the construct would spread rapidly. It should be possible to produce constructs where any potential risk of loss of male-specific expression would be negligible.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sinkins, Professor Steven |
| Authors: | Sinkins, S. P., and Hastings, I. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Trends in Parasitology |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 1471-4922 |
| ISSN (Online): | 1471-5007 |
| Published Online: | 20 July 2004 |
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