Fielding, C. A. et al. (2017) Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation. eLife, 6, e22206. (doi: 10.7554/eLife.22206) (PMID:28186488) (PMCID:PMC5367895)
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Abstract
The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel NK cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1,300 cell surface and ~7,200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Wilkie, Dr Gavin and Davison, Professor Andrew and Suarez, Dr Nicolas |
Authors: | Fielding, C. A., Weekes, M. P., Nobre, L. V., Ruckova, E., Wilkie, G. S., Paulo, J. A., Chang, C., Suárez, N., Davies, J. A., Antrobus, R., Stanton, R. J., Aicheler, R. J., Nichols, H., Vojtesek, B., Trowsdale, J., Davison, A. J., Gygi, S. P., Tomasec, P., Lehner, P. J., and Wilkinson, G. W.G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | eLife |
Publisher: | eLife Sciences Publications |
ISSN: | 2050-084X |
ISSN (Online): | 2050-084X |
Published Online: | 10 February 2017 |
Copyright Holders: | Copyright © 2017 Fielding et al. |
First Published: | First published in eLife 6: e22206 |
Publisher Policy: | Reproduced under a Creative Commons License |
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