Wounds that heal and wounds that don’t − the role of the IL-33/ST2 pathway in tissue repair and tumorigenesis

Millar, N. L. , O’Donnell, C., McInnes, I. B. and Brint, E. (2017) Wounds that heal and wounds that don’t − the role of the IL-33/ST2 pathway in tissue repair and tumorigenesis. Seminars in Cell and Developmental Biology, 61, pp. 41-50. (doi: 10.1016/j.semcdb.2016.08.007)

Abstract

IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular “alarmin”. Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McInnes, Professor Iain and Millar, Professor Neal
• Authors: Millar, N. L., O’Donnell, C., McInnes, I. B., and Brint, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Seminars in Cell and Developmental Biology
• Publisher: Elsevier
• ISSN: 1084-9521
• ISSN (Online): 1096-3634
• Published Online: 10 August 2016
• Copyright Holders: Copyright © 2016 Elsevier Ltd.
• First Published: First published in Seminars in Cell and Developmental Biology 61: 41-50
• Publisher Policy: Reproduced in accordance with the publisher copyright policy