The management of patients with aortic regurgitation and severe left ventricular dysfunction: a systematic review

Badar, A. A. et al. (2015) The management of patients with aortic regurgitation and severe left ventricular dysfunction: a systematic review. Expert Review of Cardiovascular Therapy, 13(8), pp. 915-922. (doi:10.1586/14779072.2015.1067139) (PMID:26163051)

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Abstract

A systematic search of Medline, EMBASE and CINAHL electronic databases was performed. Original research articles reporting all-cause mortality following surgery in patients with aortic regurgitation and severe left ventricular systolic dysfunction (LVSD) were identified. Nine of the 10 eligible studies were observational, single-center, retrospective analyses. Survival ranged from 86 to 100% at 30 days; 81 to 100% at 1 year and 68 to 84% at 5 years. Three studies described an improvement in mean left ventricular ejection fraction (LVEF) following aortic valve replacement (AVR) of 5–14%; a fourth study reported an increase in mean left ventricular ejection fraction (LVEF) of 9% in patients undergoing isolated AVR but not when AVR was combined with coronary artery bypass graft and/or mitral valve surgery. Three studies demonstrated improvements in functional New York Heart Association (NYHA) class following AVR. Additional studies are needed to clarify the benefits of AVR in patients with more extreme degrees of left ventricular systolic dysfunction (LVSD) and the potential roles of cardiac transplantation and transaortic valve implantation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Petrie, Professor Mark and Dobbin, Dr Stephen
Authors: Badar, A. A., Brunton, A. P.T., Mahmood, A. H., Dobbin, S., Pozzi, A., McMinn, J. F., Sinclair, A. J.E., Gardner, R. S., Petrie, M. C., Curry, P. A., Al-Attar, N. H.K., and Pettit, S. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Expert Review of Cardiovascular Therapy
Publisher:Taylor and Francis (Routledge)
ISSN:1477-9072
ISSN (Online):1744-8344
Published Online:10 July 2015

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