Laing, R. , Gillan, V. and Devaney, E. (2017) Ivermectin - old drug, new tricks? Trends in Parasitology, 33(6), pp. 463-472. (doi: 10.1016/j.pt.2017.02.004) (PMID:28285851) (PMCID:PMC5446326)
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Abstract
Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery. Although best described for its activity on glutamate-gated chloride channels in parasitic nematodes, understanding of its mode of action remains incomplete. In the field of veterinary medicine, resistance to ivermectin is now widespread, but the mechanisms underlying resistance are unresolved. Here we discuss the history of this versatile drug and its use in global health. Based on recent studies in a variety of systems, we question whether ivermectin could have additional modes of action on parasitic nematodes.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Devaney, Professor Eileen and Laing, Dr Roz and Gillan, Dr Victoria |
| Authors: | Laing, R., Gillan, V., and Devaney, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Trends in Parasitology |
| Publisher: | Elsevier |
| ISSN: | 1471-4922 |
| ISSN (Online): | 1471-5007 |
| Published Online: | 09 March 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Trends in Parasitology 33(6): 463-472 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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