Adams, D. J. , Holtzmann, K., Schneider, C. and Butler, M. F. (2007) Self-assembly of surfactant-like peptides. Langmuir, 23(25), pp. 12729-12736. (doi: 10.1021/la7011183) (PMID:17988158)
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Abstract
Inspired by recent work describing surfactant-like peptides, we have carried out a systematic study on peptides with the underlying composition of V6D2, altering the absolute sequence to determine the importance of the surfactant-like structure. All of the peptides examined here formed self-assembled structures in water. However, in contrast to other reports, we have found a surprising diversity of structures including fibers, tapes, and twisted ribbons but an absence of the vesicles and nanotubes described previously. Further investigations demonstrated that peptide purity plays a significant role in the outcome of the self-assembly. Different batches behave very differently, which can be linked to the compositions of these batches. This work shows that there is a need for not only rational design but also ease of synthesis of the building blocks for self-assembled structures.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Adams, Dave |
| Authors: | Adams, D. J., Holtzmann, K., Schneider, C., and Butler, M. F. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Langmuir |
| Publisher: | American Chemical Society |
| ISSN: | 0743-7463 |
| ISSN (Online): | 1520-5827 |
| Published Online: | 08 November 2007 |
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