Tzokova, N., Fernyhough, C. M., Topham, P. D., Sandon, N., Adams, D. J. , Butler, M. F., Armes, S. P. and Ryan, A. J. (2009) Soft hydrogels from nanotubes of poly(ethylene oxide)−tetraphenylalanine conjugates prepared by click chemistry. Langmuir, 25(4), pp. 2479-2485. (doi: 10.1021/la8035659) (PMID:19161273)
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Abstract
A new poly(ethylene oxide)−tetraphenylalanine polymer−peptide conjugate has been prepared via a “click” reaction between an alkyne-modified peptide and an azide-terminated PEO oligomer. Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer−peptide conjugate against water. The structure of these nanotubes has been probed by circular dichroism, IR, TEM, and SAXS. From these data, it is apparent that self-assembly involves the formation of antiparallel β-sheets and π−π-stacking. Nanotubes are formed at concentrations between 2 and 10 mg mL−1. Entanglement between adjacent nanotubes occurs at higher concentrations, resulting in the formation of soft hydrogels. Gel strength increases at higher polymer−peptide conjugate concentration, as expected.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Adams, Dave |
| Authors: | Tzokova, N., Fernyhough, C. M., Topham, P. D., Sandon, N., Adams, D. J., Butler, M. F., Armes, S. P., and Ryan, A. J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Langmuir |
| Publisher: | American Chemical Society |
| ISSN: | 0743-7463 |
| ISSN (Online): | 1520-5827 |
| Published Online: | 22 January 2009 |
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