Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

Zhou, K. et al. (2008) Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings. Biological Psychiatry, 64(7), pp. 571-576. (doi: 10.1016/j.biopsych.2008.02.024) (PMID:18439570) (PMCID:PMC3589988)

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Background: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Campbell, Dr Desmond
Authors: Zhou, K., Asherson, P., Sham, P., Franke, B., Anney, R. J.L., Buitelaar, J., Ebstein, R., Gill, M., Brookes, K., Buschgens, C., Campbell, D., Chen, W., Christiansen, H., Fliers, E., Gabriëls, I., Johansson, L., Marco, R., Mulas, F., Müller, U., Mulligan, A., Neale, B. M., Rijsdijk, F., Rommelse, N., Uebel, H., Psychogiou, L., Xu, X., Banaschewski, T., Sonuga-Barke, E., Eisenberg, J., Manor, I., Miranda, A., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H.-C., Taylor, E., Thompson, M., and Faraone, S. V.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Biological Psychiatry
ISSN (Online):1873-2402
Published Online:24 April 2008

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