Schridde, A. et al. (2017) Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling. Mucosal Immunology, 10, pp. 1387-1399. (doi: 10.1038/mi.2016.142) (PMID:28145440) (PMCID:PMC5417360)
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Abstract
Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. Here we have used global transcriptomic analysis to identify a unique homeostatic signature of mature colonic mφ that is acquired as they differentiate in the mucosa. By comparing the analogous monocyte differentiation process found in the dermis, we identify TGFβ as an indispensable part of monocyte differentiation in the intestine and show that it enables mφ to adapt precisely to the requirements of their environment. Importantly, TGFβR signaling on mφ has a crucial role in regulating the accumulation of monocytes in the mucosa, via mechanisms that are distinct from those used by IL10.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mowat, Professor Allan and Montgomery, Dr Jennifer and Mayer, Mr Johannes and Bain, Mr Calum and Schridde, Ms Anika and Milling, Professor Simon |
| Authors: | Schridde, A., Bain, C.C., Mayer, J.U., Montgomery, J., Pollet, E., Denecke, B., Milling, S.W.F., Jenkins, S. J., Dalod, M., Henri, S., Malissen, B., Pabst, O., and Mcl. Mowat, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Mucosal Immunology |
| Publisher: | Nature Publishing Group |
| ISSN: | 1933-0219 |
| ISSN (Online): | 1935-3456 |
| Published Online: | 01 February 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Mucosal Immunology 2017 10:1387-1399 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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