Petrie, M. C., Traynor, J. P. and Mactier, R. A. (2016) Incidence and outcome of encapsulating peritoneal sclerosis. Clinical Kidney Journal, 9(4), pp. 624-629. (doi: 10.1093/ckj/sfw051) (PMID:27478609) (PMCID:PMC4957727)
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Abstract
Background: Studies report variation in the incidence and outcomes of encapsulating peritoneal sclerosis (EPS). This study reports the incidence and outcome of EPS cases in a national cohort of peritoneal dialysis (PD) patients. Methods: The incident cohort of adult patients who started PD between 1 January 2000 and 31 December 2007 in Scotland (n = 1238) was identified from the Scottish Renal Registry. All renal units in Scotland identified potential EPS cases diagnosed from 1 January 2000 to 31 December 2014, by which point all patients had a minimum of 7 years follow-up from start of PD. Results: By 31 December 2014, 35 EPS cases were diagnosed in the 1238 patient cohort: an overall incidence of 2.8%. The incidence for subgroups with longer PD duration rises exponentially: 1.1% by 1 year, 3.4% by 3 years, 8.8% at 4 years, 9.4% at 5 years and 22.2% by 7 years. Outcomes are poor with mortality of 57.1% by 1 year after diagnosis. Survival analysis demonstrates an initial above-average survival in patients who later develop EPS, which plummets to well below average after EPS diagnosis. Conclusions: The incidence of EPS is reassuringly low provided PD exposure is not prolonged and this supports ongoing use of PD. However, continuing PD beyond 3 years results in an exponential rise in the risk of developing EPS and deciding whether this risk is acceptable should be made on an individual patient basis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Traynor, Dr Jamie and MacTier, Dr Robert |
| Authors: | Petrie, M. C., Traynor, J. P., and Mactier, R. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Clinical Kidney Journal |
| Publisher: | Oxford University Press |
| ISSN: | 2048-8505 |
| ISSN (Online): | 2048-8513 |
| Published Online: | 20 June 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Clinical Kidney Journal 9(4):624-629 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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