Analysis of the aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) genes

MacKenzie, S. M. , Davies, E. and Alvarez-Madrazo, S. (2017) Analysis of the aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) genes. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 139-150. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_11)

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The aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) enzymes are known to be important players in the development of hypertension. Sequencing of the CYP11B2 and CYP11B1 genes and quantification of their respective mRNAs is greatly complicated by their high degree of sequence similarity. The need to ensure gene specificity during such analysis has required the development of particular methods for the detection of key polymorphisms at these loci, which are detailed in this chapter.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Davies, Professor Eleanor and MacKenzie, Dr Scott
Authors: MacKenzie, S. M., Davies, E., and Alvarez-Madrazo, S.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Published Online:24 January 2017

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