Life expectancy and cause-specific mortality in type 2 diabetes: a population-based cohort study quantifying relationships in ethnic subgroups

Wright, A. K., Kontopantelis, E., Emsley, R., Buchan, I., Sattar, N. , Rutter, M. K. and Ashcroft, D. M. (2017) Life expectancy and cause-specific mortality in type 2 diabetes: a population-based cohort study quantifying relationships in ethnic subgroups. Diabetes Care, 40(3), pp. 338-345. (doi: 10.2337/dc16-1616) (PMID:27998911)

Abstract

Objectives: This study 1) investigated life expectancy and cause-specific mortality rates associated with type 2 diabetes and 2) quantified these relationships in ethnic subgroups. Reasearch Design and Methods: This was a cohort study using Clinical Practice Research Datalink data from 383 general practices in England with linked hospitalization and mortality records. A total of 187,968 patients with incident type 2 diabetes from 1998 to 2015 were matched to 908,016 control subjects. Abridged life tables estimated years of life lost, and a competing risk survival model quantified cause-specific hazard ratios (HRs). Results: A total of 40,286 deaths occurred in patients with type 2 diabetes. At age 40, white men with diabetes lost 5 years of life and white women lost 6 years compared with those without diabetes. A loss of between 1 and 2 years was observed for South Asian and blacks with diabetes. At age older than 65 years, South Asians with diabetes had up to 1.1 years’ longer life expectancy than South Asians without diabetes. Compared with whites with diabetes, South Asians with diabetes had lower adjusted risks for mortality from cardiovascular (HR 0.82 [95% CI 0.75–0.89]), cancer (HR 0.43 [95% CI 0.36–0.51]), and respiratory diseases (HR 0.60 [95% CI 0.48–0.76]). A similar pattern was observed in blacks with diabetes compared with whites with diabetes. Conclusions: Type 2 diabetes was associated with more years of life lost among whites than among South Asians or blacks, with older South Asians experiencing longer life expectancy compared with South Asians without diabetes. The findings support optimized cardiovascular disease risk factor management, especially in whites with type 2 diabetes.

• Item Type: Articles
• Additional Information: This study was funded by Diabetes UK (BDA: 14/0004971). Medical Research Council eResearch Centre Grant MR/K006665/1 supported the time and facilities of E.K. and I.B.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sattar, Professor Naveed
• Authors: Wright, A. K., Kontopantelis, E., Emsley, R., Buchan, I., Sattar, N., Rutter, M. K., and Ashcroft, D. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Diabetes Care
• Publisher: American Diabetes Association
• ISSN: 0149-5992
• ISSN (Online): 1935-5548
• Published Online: 19 December 2016
• First Published: First published in Diabetes Care 40(3):338-345
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher