Köster, L., Shell, L., Ketzis, J., Rajeev, S. and Illanes, O. (2017) Diagnosis of pancreatic disease in feline platynosomosis. Journal of Feline Medicine and Surgery, 19(2), pp. 1192-1198. (doi: 10.1177/1098612X16685676) (PMID:28094661)
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Abstract
Objectives: Platynosomum species are cat-specific parasitic trematodes that parasitize the biliary ducts and gall bladder. Due to the common connection to the major duodenal papilla of the pancreas and common bile ducts in addition to the periductal proximity of the pancreas, it is possible that platynosomosis could cause pancreatitis. The objective of this study was to determine whether platynosomosis, a commonly diagnosed parasitic disease in cats on St Kitts, has any association with pancreatic disease. Methods: To investigate this possibility, the pancreas of free-roaming cats with naturally acquired platynosomosis were evaluated via ultrasound, serum concentrations of feline pancreatic lipase (fPL), cobalamin, folate and feline trypsin-like immunoreactivity (fTLI) and histopathology. Twenty free-roaming, young adult, feral cats, positive for feline immunodeficiency virus, and diagnosed with Platynosomum species infection via fecal analysis were recruited. The liver, biliary system and pancreas were evaluated via ultrasonography during a short duration anesthesia. Serum concentrations of fPL, fTLI, folate and cobalamin were measured. Sections of the right limb, left limb and body of the pancreas were evaluated histopathologically using hematoxylin and eosin (H&E) stain. Results: None of the cats had sufficient criteria to fulfill the ultrasonographic diagnosis of pancreatitis. One cat had an elevated fPL concentration in the range consistent with pancreatitis. Four cats had cobalamin deficiencies and 11 had abnormal folate concentration. The fTLI concentration was equivocal for the diagnosis of exocrine pancreatic insufficiency in one cat. With a single exception, histopathology changes, when present (n = 12), were mild, non-specific and predominantly characterized by lymphocytic infiltrates and fibrosis. The exception was a cat that presented a chronic interstitial and eosinophilic pancreatitis of slightly increased severity, likely the result of platynosomosis. Conclusions and relevance: The results of this study suggest that platynosomosis rarely induces pancreatic damage in cats. With only one exception, chronic pancreatitis diagnosed in cats with fluke-induced cholangitis and cholangiohepatitis was subtle and interpreted as an incidental background lesion unrelated to platynosomosis.
| Item Type: | Articles |
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| Additional Information: | Partial funding for this study was provided under a grant from the National Center for Veterinary Parasitology at Oklahoma State University. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Koster, Dr Liza |
| Authors: | Köster, L., Shell, L., Ketzis, J., Rajeev, S., and Illanes, O. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Journal of Feline Medicine and Surgery |
| Publisher: | SAGE |
| ISSN: | 1098-612X |
| ISSN (Online): | 1532-2750 |
| Published Online: | 17 January 2017 |
| Copyright Holders: | Copyright © 2017 SAGE Publications |
| First Published: | First published in Journal of Feline Medicine and Surgery 19(2):1192-1198 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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