From single-cell dynamics to scaling laws in oncology

Chignola, R., Sega, M., Stella, S., Vyshemirsky, V. and Milotti, E. (2014) From single-cell dynamics to scaling laws in oncology. Biophysical Reviews and Letters, 9(3), pp. 273-284. (doi: 10.1142/S1793048014300035)

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We are developing a biophysical model of tumor biology. We follow a strictly quantitative approach where each step of model development is validated by comparing simulation outputs with experimental data. While this strategy may slow down our advancements, at the same time it provides an invaluable reward: we can trust simulation outputs and use the model to explore territories of cancer biology where current experimental techniques fail. Here, we review our multi-scale biophysical modeling approach and show how a description of cancer at the cellular level has led us to general laws obeyed by both in vitro and in vivo tumors.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Vyshemirsky, Dr Vladislav
Authors: Chignola, R., Sega, M., Stella, S., Vyshemirsky, V., and Milotti, E.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Biophysical Reviews and Letters
Publisher:World Scientific Publishing Company
ISSN (Online):1793-7035
Published Online:25 July 2014

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