Interplay between distribution of live cells and growth dynamics of solid tumours

Milotti, E., Vyshemirsky, V. , Sega, M. and Chignola, R. (2012) Interplay between distribution of live cells and growth dynamics of solid tumours. Scientific Reports, 2, 990. (doi: 10.1038/srep00990) (PMID:23251776) (PMCID:PMC3524520)

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Experiments show that simple diffusion of nutrients and waste molecules is not sufficient to explain the typical multilayered structure of solid tumours, where an outer rim of proliferating cells surrounds a layer of quiescent but viable cells and a central necrotic region. These experiments challenge models of tumour growth based exclusively on diffusion. Here we propose a model of tumour growth that incorporates the volume dynamics and the distribution of cells within the viable cell rim. The model is suggested by in silico experiments and is validated using in vitro data. The results correlate with in vivo data as well, and the model can be used to support experimental and clinical oncology.

Item Type:Articles
Additional Information:A correction to this article is available at
Glasgow Author(s) Enlighten ID:Vyshemirsky, Dr Vladislav
Authors: Milotti, E., Vyshemirsky, V., Sega, M., and Chignola, R.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in Scientific Reports 2: 990
Publisher Policy:Reproduced under a Creative Commons License
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