Huang, J., Hastings, C. L., Duffy, G. P., Kelly, H. M., Raeburn, J., Adams, D. J. and Heise, A. (2013) Supramolecular hydrogels with reverse thermal gelation properties from (oligo)tyrosine containing block copolymers. Biomacromolecules, 14(1), pp. 200-206. (doi: 10.1021/bm301629f)
Full text not currently available from Enlighten.
Abstract
Novel block copolymers comprising poly(ethylene glycol) (PEG) and an oligo(tyrosine) block were synthesized in different compositions by N-carboxyanhydride (NCA) polymerization. It was shown that PEG2000-Tyr6 undergoes thermoresponsive hydrogelation at a low concentration range of 0.25–3.0 wt % within a temperature range of 25–50 °C. Cryogenic transmission electron microscopy (Cryo-TEM) revealed a continuous network of fibers throughout the hydrogel sample, even at concentrations as low as 0.25 wt %. Circular dichroism (CD) results suggest that better packing of the β-sheet tyrosine block at increasing temperature induces the reverse thermogelation. A preliminary assessment of the potential of the hydrogel for in vitro application confirmed the hydrogel is not cytotoxic, is biodegradable, and produced a sustained release of a small-molecule drug.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Adams, Dave |
Authors: | Huang, J., Hastings, C. L., Duffy, G. P., Kelly, H. M., Raeburn, J., Adams, D. J., and Heise, A. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Biomacromolecules |
Publisher: | American Chemical Society |
ISSN: | 1525-7797 |
ISSN (Online): | 1526-4602 |
Published Online: | 28 November 2012 |
University Staff: Request a correction | Enlighten Editors: Update this record