The role of extracellular vesicles in Plasmodium and other protozoan parasites

Mantel, P.-Y. and Marti, M. (2014) The role of extracellular vesicles in Plasmodium and other protozoan parasites. Cellular Microbiology, 16(3), pp. 344-354. (doi: 10.1111/cmi.12259) (PMID:24406102) (PMCID:PMC3965572)

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Protozoan parasites and other microorganisms use various pathways to communicate within their own populations and to manipulate their outside environments, with the ultimate goal of balancing the rate of growth and transmission. In higher eukaryotes, including humans, circulating extracellular vesicles are increasingly recognized as key mediators of physiological and pathological processes. Recent evidence suggests that protozoan parasites, including those responsible for major human diseases such as malaria and Chagas disease, use similar machinery. Indeed, intracellular and extracellular protozoan parasites secrete extracellular vesicles to promote growth and induce transmission, to evade the host immune system, and to manipulate the microenvironment. In this review we will discuss the general pathways of extracellular vesicle biogenesis and their functions in protozoan infections.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Marti, Professor Matthias
Authors: Mantel, P.-Y., and Marti, M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Cellular Microbiology
ISSN (Online):1462-5822
Published Online:10 January 2014

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