Microultrasound characterisation of ex vivo porcine tissue for ultrasound capsule endoscopy

Lay, H.S. , Cox, B.F., Sunoqrot, M., Démoré, C.E.M., Näthke, I., Gomez, T. and Cochran, S. (2017) Microultrasound characterisation of ex vivo porcine tissue for ultrasound capsule endoscopy. Journal of Physics: Conference Series, 797(1), 012003. (doi: 10.1088/1742-6596/797/1/012003)

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Gastrointestinal (GI) disease development and progression is often characterised by cellular and tissue architectural changes within the mucosa and sub-mucosa layers. Current clinical capsule endoscopy and other approaches are heavily reliant on optical techniques which cannot detect disease progression below the surface layer of the tissue. To enhance the ability of clinicians to detect cellular changes earlier and more confidently, both quantitative and qualitative microultrasound (μUS) techniques are investigated in healthy ex vivo porcine GI tissue. This work is based on the use of single-element, focussed μUS transducers made with micromoulded piezocomposite operating at around 48 MHz. To explore the possibility that μUS can detect Crohn's disease and other inflammatory bowel diseases, ex vivo porcine small bowel tissue samples were cannulised and perfused with phosphate-buffered saline followed by various dilutions of polystyrene microspheres. Comparison with fluorescent imaging showed that the microspheres had infiltrated the microvasculature of the samples and that μUS was able to successfully detect this as a mimic of inflammation. Samples without microspheres were analysed using quantitative ultrasound to assess mechanical properties. Attenuation coefficients of 1.78 ± 0.66 dB/mm and 1.92 ± 0.77 dB/mm were obtained from reference samples which were surgically separated from the muscle layer. Six intact samples were segmented using a software algorithm and the acoustic impedance, Z, for varying tissue thicknesses, and backscattering coefficient, BSC, were calculated using the reference attenuation values and tabulated.

Item Type:Articles
Additional Information:15th Anglo‐French Physical Acoustics Conference (AFPAC 2016) 13–15 January 2016, Surrey, United Kingdom
Glasgow Author(s) Enlighten ID:Cox, Dr Benjamin F and Lay, Dr Holly
Authors: Lay, H.S., Cox, B.F., Sunoqrot, M., Démoré, C.E.M., Näthke, I., Gomez, T., and Cochran, S.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Journal of Physics: Conference Series
Publisher:Institute of Physics Publishing Ltd.
ISSN (Online):1742-6596
Published Online:18 January 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Journal of Physics: Conference Series 797(1):012003
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
615381Sonopill: minimally invasive gastrointestinal diagnosis and therapyDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/K034537/1ENG - ENGINEERING ELECTRONICS & NANO ENG