Frog foams and natural protein surfactants

Cooper, A., Vance, S. J., Smith, B. O. and Kennedy, M. W. (2017) Frog foams and natural protein surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 534, pp. 120-129. (doi: 10.1016/j.colsurfa.2017.01.049) (PMID:29276339) (PMCID:PMC5727673)

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Foams and surfactants are relatively rare in biology because of their potential to harm cell membranes and other delicate tissues. However, in recent work we have identified and characterized a number of natural surfactant proteins found in the foam nests of tropical frogs and other unusual sources. These proteins, and their associated foams, are relatively stable and bio-compatible, but with intriguing molecular structures that reveal a new class of surfactant activity. Here we review the structures and functional mechanisms of some of these proteins as revealed by experiments involving a range of biophysical and biochemical techniques, with additional mechanistic support coming from more recent site-directed mutagenesis studies.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Kennedy, Professor Malcolm and Smith, Dr Brian and Cooper, Professor Alan
Authors: Cooper, A., Vance, S. J., Smith, B. O., and Kennedy, M. W.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Science and Engineering > School of Chemistry
Journal Name:Colloids and Surfaces A: Physicochemical and Engineering Aspects
ISSN (Online):1873-4359
Published Online:21 January 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Colloids and Surfaces A: Physicochemical and Engineering Aspects 534:120-129
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
350081Latherin - a natural surfactant protein for biomedical and environmental applicationsMalcolm KennedyWellcome Trust (WELLCOME)070994/Z/03/ZLS - ANIMAL BIOLOGY