Cutting edge: helminth infection induces IgE in the absence of μ- or δ-chain expression

Perona-Wright, G. , Mohrs, K., Taylor, J., Zaph, C., Artis, D., Pearce, E. J. and Mohrs, M. (2008) Cutting edge: helminth infection induces IgE in the absence of μ- or δ-chain expression. Journal of Immunology, 181(10), pp. 6697-6701. (doi: 10.4049/jimmunol.181.10.6697) (PMID:18981085) (PMCID:PMC3066072)

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Abstract

Infections with helminth parasites are associated with an IgE isotype switch and high serum IgE concentrations. IgE is rapidly bound by the high affinity IgE receptor (FcεRI), thereby sensitizing FcεRI-bearing basophils and mast cells for IgE-inducible effector functions such as IL-4 production. The development of Ab-secreting B cells is dependent on IgM and consequently, μMT mice, which lack surface IgM, are considered devoid of Abs. In this study we report the unexpected finding that C57BL/6 μMT mice generate robust IgE responses upon infection with three distinct helminth parasites, Heligmosomoides polygyrus, Trichuris muris, and Schistosoma mansoni. IgE is produced despite an apparent block in B cell development and licenses basophils for IgE-induced IL-4 production. Our findings reveal the existence of an evolutionarily conserved, IgM-independent pathway for the production of IgE upon infection with helminth parasites.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Perona-Wright, Dr Georgia
Authors: Perona-Wright, G., Mohrs, K., Taylor, J., Zaph, C., Artis, D., Pearce, E. J., and Mohrs, M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Immunology
Publisher:American Association of Immunologists
ISSN:0022-1767
ISSN (Online):1550-6606
Published Online:03 November 2008

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