Perona-Wright, G. , Jenkins, S. J., Crawford, A., Gray, D., Pearce, E. J. and MacDonald, A. S. (2006) Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. European Journal of Immunology, 36(9), pp. 2367-2375. (doi: 10.1002/eji.200535722) (PMID:16917957)
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Abstract
Dendritic cells (DC) can both initiate an immune response and dictate its character. Cytokines are critically involved in this process and, although interleukin (IL)-10 is known as a potent immunosuppressant, the impact of its release from DC remains unclear. Here, we transfer pathogen-conditioned murine DC in vivo and show that, while DC-derived IL-10 can act to limit Th1 development, it is not required for Th2 induction. In both Th2 and Th1 settings, however, IL-10 from cells other than the initiating DC dominates the regulation of the emerging effector cell populations. Surprisingly, the critical source of IL-10 in this process is neither T nor B cells. These data illustrate the distinct actions of IL-10 during differently polarised, pathogen-focussed, DC-driven immune responses in vivo.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Perona-Wright, Dr Georgia |
| Authors: | Perona-Wright, G., Jenkins, S. J., Crawford, A., Gray, D., Pearce, E. J., and MacDonald, A. S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | European Journal of Immunology |
| Publisher: | Wiley-VCH Verlag |
| ISSN: | 0014-2980 |
| ISSN (Online): | 1521-4141 |
| Published Online: | 18 August 2006 |
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