Glatzel, S., Hezwani, M., Kitson, P. J., Gromski, P. S., Schürer, S. and Cronin, L. (2016) A portable 3D printer system for the diagnosis and treatment of multidrug-resistant bacteria. Chem, 1(3), pp. 494-504. (doi: 10.1016/j.chempr.2016.08.008)
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Abstract
Summary: Multidrug-resistant bacteria are a major threat to human health, but broad-spectrum antibiotics are losing efficacy. There is a need to screen a given drug against a bacterial infection outside of the laboratory. To address this need, we have designed and built an inexpensive and easy-to-use 3D-printer-based system that allows easily readable quantitative tests for the performance of antibacterial drugs. The platform creates a sterile diagnostic device by using 3D printing, and the device is filled automatically with growth medium, and then antibiotics are sprayed onto the medium by ink-jet technology. The sample for testing can be introduced via a fluid port, and the printer hot bed is used to incubate the device, allowing operation in the field. Combining advantages from various established tests of antibacterial performance, this allows the comparison of a specific antibiotics and bacteria. Also, this system can create and test several antibiotic formulations for therapeutic use, and we demonstrate this potential by investigating a mixture of pathogens that are only killed by a mixture of drugs.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gromski, Dr Piotr and Hezwani, Dr Mohammed and Cronin, Professor Lee and Kitson, Dr Philip and Glatzel, Dr Stefan |
| Authors: | Glatzel, S., Hezwani, M., Kitson, P. J., Gromski, P. S., Schürer, S., and Cronin, L. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Chem |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 2451-9308 |
| ISSN (Online): | 2451-9294 |
| Published Online: | 08 September 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Chem 1(3):494-504 |
| Publisher Policy: | Reproduced under a creative commons license |
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