Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Tauchen, J. et al. (2016) Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon. Revista Brasileira de Farmacognosia, 26(6), pp. 728-737. (doi: 10.1016/j.bjp.2016.03.016)

Abstract

Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 μg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 μg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 μg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 μg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Havlik, Dr Jaroslav
• Authors: Tauchen, J., Bortl, L., Huml, L., Miksatkova, P., Doskocil, I., Marsik, P., Villegas, P. P. P., Flores, Y. B., Van Damme, P., Lojka, B., Havlik, J., Lapcik, O., and Kokoska, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Revista Brasileira de Farmacognosia
• Publisher: Elsevier
• ISSN: 0102-695X
• ISSN (Online): 1981-528X
• Published Online: 14 June 2016
• Copyright Holders: Copyright © 2016 Sociedade Brasileira de Farmacognosia
• First Published: First published in Revista Brasileira de Farmacognosia 26(6):728-737
• Publisher Policy: Reproduced under a creative commons license