Cancer metabolism at a glance

Vazquez, A., Kamphorst, J. J. , Markert, E. K., Schug, Z. T., Tardito, S. and Gottlieb, E. (2016) Cancer metabolism at a glance. Journal of Cell Science, 129(18), pp. 3367-3373. (doi: 10.1242/jcs.181016) (PMID:27635066)

Abstract

A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and anabolic demands of enhanced cell proliferation. How these metabolic requirements are satisfied depends, in part, on the tumor microenvironment, which determines the availability of nutrients and oxygen. In this Cell Science at a Glance paper and the accompanying poster, we summarize our current understanding of cancer metabolism, emphasizing pathways of nutrient utilization and metabolism that either appear or have been proven essential for cancer cells. We also review how this knowledge has contributed to the development of anticancer therapies that target cancer metabolism.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Tardito, Dr Saverio and Kamphorst, Dr Jurre and Markert, Dr Elke and Gottlieb, Professor Eyal and Vazquez, Alexei and Schug, Dr Zachary
• Authors: Vazquez, A., Kamphorst, J. J., Markert, E. K., Schug, Z. T., Tardito, S., and Gottlieb, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Journal of Cell Science
• Publisher: Company of Biologists
• ISSN: 0021-9533
• ISSN (Online): 1477-9137
• Published Online: 15 September 2016
• Copyright Holders: Copyright © 2016 The Authors
• First Published: First published in Journal of Cell Science 129(18):3367-3373
• Publisher Policy: Reproduced under a Creative Commons License