Discriminating valid from spurious indices of phase-amplitude coupling

Jensen, O., Spaak, E. and Park, H. (2016) Discriminating valid from spurious indices of phase-amplitude coupling. eNeuro, 3(6), e0334-16.2. (doi: 10.1523/ENEURO.0334-16.2016) (PMID:28101528) (PMCID:PMC5237829)

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Abstract

Recently there has been a strong interest in cross-frequency coupling, the interaction between neuronal oscillations in different frequency bands. In particular, measures quantifying the coupling between the phase of slow oscillations and the amplitude of fast oscillations have been applied to a wide range of data recorded from animals and humans. Some of the measures applied to detect phase-amplitude coupling have been criticized for being sensitive to non-sinusoidal properties of the oscillations and thus spuriously indicate the presence of coupling. While such instances of spurious identification of coupling have been observed, in this commentary we give concrete examples illustrating cases when the identification of cross-frequency coupling can be trusted. These examples are based on control analyses and empirical observations rather than signal processing tools. Finally, we provide concrete advice on how to determine when measures of phase-amplitude coupling can be considered trustworthy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Park, Dr Hyojin
Authors: Jensen, O., Spaak, E., and Park, H.
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:eNeuro
Publisher:Society for Neuroscience
ISSN:2373-2822
ISSN (Online):2373-2822
Published Online:26 December 2016
Copyright Holders:Copyright © 2016 Jensen et al.
First Published:First published in eNeuro 3(6):e0334-16.2016
Publisher Policy:Reproduced under a Creative Commons License

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