Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol

Karim, R., Somani, S., Al Robaian, M., Mullin, M., Amor, R., McConnell, G. and Dufès, C. (2017) Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol. Journal of Controlled Release, 246, pp. 79-87. (doi: 10.1016/j.jconrel.2016.12.014) (PMID:27993600)

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Abstract

The therapeutic potential of tocotrienol, a member of the vitamin E family of compounds with potent in vitro anti-cancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study is to determine whether a novel tumor-targeted vesicular formulation of tocotrienol would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. In this work, we demonstrated that novel transferrin-bearing multilamellar vesicles entrapping α-T3 resulted in a dramatically improved (by at least 52-fold) therapeutic efficacy in vitro on A431 cell line, compared to the free drug. In addition, the intravenous administration of tocotrienol entrapped in transferrin-bearing vesicles resulted in tumor suppression for 30% of A431 and 60% of B16-F10 tumors, without visible toxicity. Mouse survival was enhanced by > 13 days compared to controls administered with the drug solution only. This tumor-targeted, tocotrienol-based nanomedicine therefore significantly improved the therapeutic response in cancer treatment.

Item Type:Articles
Additional Information:This work was financially supported by the University of Strathclyde. The IVIS was funded with an equipment grant (No. ME0442) from The Wellcome Trust.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mullin, Mrs Margaret
Authors: Karim, R., Somani, S., Al Robaian, M., Mullin, M., Amor, R., McConnell, G., and Dufès, C.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Journal of Controlled Release
Publisher:Elsevier
ISSN:0168-3659
ISSN (Online):1873-4995
Published Online:18 December 2016

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