Karim, R., Somani, S., Al Robaian, M., Mullin, M., Amor, R., McConnell, G. and Dufès, C. (2017) Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol. Journal of Controlled Release, 246, pp. 79-87. (doi: 10.1016/j.jconrel.2016.12.014) (PMID:27993600)
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Abstract
The therapeutic potential of tocotrienol, a member of the vitamin E family of compounds with potent in vitro anti-cancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study is to determine whether a novel tumor-targeted vesicular formulation of tocotrienol would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. In this work, we demonstrated that novel transferrin-bearing multilamellar vesicles entrapping α-T3 resulted in a dramatically improved (by at least 52-fold) therapeutic efficacy in vitro on A431 cell line, compared to the free drug. In addition, the intravenous administration of tocotrienol entrapped in transferrin-bearing vesicles resulted in tumor suppression for 30% of A431 and 60% of B16-F10 tumors, without visible toxicity. Mouse survival was enhanced by > 13 days compared to controls administered with the drug solution only. This tumor-targeted, tocotrienol-based nanomedicine therefore significantly improved the therapeutic response in cancer treatment.
Item Type: | Articles |
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Additional Information: | This work was financially supported by the University of Strathclyde. The IVIS was funded with an equipment grant (No. ME0442) from The Wellcome Trust. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mullin, Mrs Margaret |
Authors: | Karim, R., Somani, S., Al Robaian, M., Mullin, M., Amor, R., McConnell, G., and Dufès, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
Journal Name: | Journal of Controlled Release |
Publisher: | Elsevier |
ISSN: | 0168-3659 |
ISSN (Online): | 1873-4995 |
Published Online: | 18 December 2016 |
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