Yakob, L., Lloyd, A. L., Kao, R. R., Ferguson, H. M. , Brock, P. M. , Drakeley, C. and Bonsall, M. B. (2018) Plasmodium knowlesi invasion following spread by infected mosquitoes, macaques and humans. Parasitology, 145, pp. 101-110. (doi: 10.1017/S0031182016002456) (PMID:28345507)
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Abstract
Plasmodium knowlesi is increasingly recognised as a major cause of malaria in Southeast Asia. 24 Anopheles leucosphyrous group mosquitoes transmit the parasite and natural hosts include long-tailed and pig-tailed macaques. Despite early laboratory experiments demonstrating successful passage of infection between humans, the true role that humans play in P. knowlesi epidemiology remains unclear. The threat posed by its introduction into immunologically naïve populations is unknown despite being a public health priority for this region. A two-host species mathematical model was constructed to analyse this threat. Global sensitivity analysis using Monte Carlo methods highlighted the biological processes of greatest influence to transmission. These included parameters known to be influential in classic mosquito-borne disease models (e.g. vector longevity); however, interesting ecological components that are specific to this system were also highlighted: while local vectors likely have intrinsic preferences for certain host species, how plastic these preferences are, and how this is shaped by local conditions, are key determinants of parasite transmission potential. Invasion analysis demonstrates that this behavioural plasticity can qualitatively impact the probability of an epidemic sparked by imported infection. Identifying key vector sub/species and studying their biting behaviours constitute important next steps before models can better assist in strategizing disease control.
| Item Type: | Articles |
|---|---|
| Additional Information: | Volume 145, Special Issue 1 (Plasmodium knowlesi). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kao, Professor Rowland and Ferguson, Professor Heather and Brock, Dr Patrick |
| Authors: | Yakob, L., Lloyd, A. L., Kao, R. R., Ferguson, H. M., Brock, P. M., Drakeley, C., and Bonsall, M. B. |
| Subjects: | Q Science > QL Zoology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Parasitology |
| Publisher: | Cambridge University Press |
| ISSN: | 0031-1820 |
| ISSN (Online): | 1469-8161 |
| Published Online: | 27 March 2017 |
| Copyright Holders: | Copyright © 2017 Cambridge University Press |
| First Published: | First published in Parasitology 145:101-110 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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