Kulikov, V., Johnson, N. A.B., Surman, A. J. , Hutin, M., Kelly, S. K. , Hezwani, M., Long, D.-L. , Meyer, G. and Cronin, L. (2017) Spontaneous assembly of an organic-inorganic nucleic acid Z-DNA double-helix structure. Angewandte Chemie (International Edition), 56(4), pp. 1141-1145. (doi: 10.1002/anie.201606658) (PMID:27900812) (PMCID:PMC6057607)
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Abstract
Herein, we report a hybrid polyoxometalate organic–inorganic compound, Na2[(HGMP)2Mo5O15]⋅7 H2O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally occurring left-handed Z-form of DNA. The helical parameters in the crystal structure of the new compound, such as rise per turn and helical twist per dimer, are nearly identical to this DNA conformation, allowing a close comparison of the two structures. Solution circular dichroism studies show that compound 1 also forms extended secondary structures in solution. Gel electrophoresis studies demonstrate the formation of non-covalent adducts with natural plasmids. Thus we show a route by which simple hybrid inorganic–organic monomers, such as compound 1, can spontaneously assemble into a double helix without the need for a covalently connected linear sequence of nucleic acid base pairs.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hutin, Dr Marie and Hezwani, Dr Mohammed and Kulikov, Dr Vladislav and Long, Dr Deliang and Kelly, Dr Sharon and Johnson, Ms Naomi and Cronin, Professor Lee and Surman, Dr Andrew |
| Authors: | Kulikov, V., Johnson, N. A.B., Surman, A. J., Hutin, M., Kelly, S. K., Hezwani, M., Long, D.-L., Meyer, G., and Cronin, L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Chemistry |
| Journal Name: | Angewandte Chemie (International Edition) |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| ISSN: | 1433-7851 |
| ISSN (Online): | 1521-3773 |
| Published Online: | 30 November 2016 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Angewandte Chemie (International ed. in English) 56(4):1141-1145 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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