The role of hypoxia in inflammatory disease (Review)

Biddlestone, J., Bandarra, D. and Rocha, S. (2015) The role of hypoxia in inflammatory disease (Review). International Journal of Molecular Medicine, 35(4), pp. 859-869. (doi: 10.3892/ijmm.2015.2079) (PMID:25625467) (PMCID:PMC4356629)

Abstract

Mammals have developed evolutionarily conserved programs of transcriptional response to hypoxia and inflammation. These stimuli commonly occur together in vivo and there is significant crosstalk between the transcription factors that are classically understood to respond to either hypoxia or inflammation. This crosstalk can be used to modulate the overall response to environmental stress. Several common disease processes are characterised by aberrant transcriptional programs in response to environmental stress. In this review, we discuss the current understanding of the role of the hypoxia-responsive (hypoxia-inducible factor) and inflammatory (nuclear factor-κB) transcription factor families and their crosstalk in rheumatoid arthritis, inflammatory bowel disease and colorectal cancer, with relevance for future therapies for the management of these conditions.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Biddlestone, Dr John
• Authors: Biddlestone, J., Bandarra, D., and Rocha, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: International Journal of Molecular Medicine
• Publisher: Spandidos Publications
• ISSN: 1107-3756
• ISSN (Online): 1791-244X
• Published Online: 27 January 2015
• Copyright Holders: Copyright © 2015 Biddlestone et al.
• First Published: First published in International Journal of Molecular Medicine 35(4):859-869
• Publisher Policy: Reproduced under a Creative Commons License