Fontaine, S.J. , Mcculloch, E. , Eckersall, P.D. , Haining, H., Patterson Kane, J.C. and Morris, J.S. (2017) Evaluation of the modified Glasgow Prognostic Score to predict outcome in dogs with newly diagnosed lymphoma. Veterinary and Comparative Oncology, 15(4), pp. 1513-1526. (doi: 10.1111/vco.12296) (PMID:28150446)
|
Text
131844.pdf - Accepted Version 837kB |
Abstract
The modified Glasgow Prognostic Score (mGPS) assigns a numerical value (0–2) from pre-treatment serum concentrations of C-reactive protein (CRP) and albumin to predict patient outcome. CRP and albumin were evaluated in 77 untreated dogs with lymphoma to determine the relationship of mGPS to clinicopathological parameters and whether it could predict progression-free (PFS) and overall survival (OS) in treated dogs. mGPS distribution was significantly associated with clinical stage, substage b, weight loss, gastrointestinal disturbances and lethargy at presentation. On univariate analysis, mGPS was significantly associated with OS and PFS, with shorter median survival times for mGPS 2 compared to mGPS 0 and 1 combined. Hypoalbuminaemia significantly reduced OS and PFS, however increased CRP had no effect. Only clinical stage was significantly associated with OS and PFS on both univariate and multivariate analysis. mGPS has potential prognostic value for canine lymphoma , but further studies are needed.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Eckersall, Professor David and Morris, Professor Joanna and Fontaine, Ms Samantha and Haining, Dr Hayley and Mcculloch, Miss Eilidh |
| Authors: | Fontaine, S.J., Mcculloch, E., Eckersall, P.D., Haining, H., Patterson Kane, J.C., and Morris, J.S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Veterinary and Comparative Oncology |
| Publisher: | Wiley |
| ISSN: | 1476-5810 |
| ISSN (Online): | 1476-5829 |
| Published Online: | 02 February 2017 |
| Copyright Holders: | Copyright © 2017 John Wiley and Sons Ltd |
| First Published: | First published in Veterinary and Comparative Oncology 15(4): 1513-1526 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric