Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction

Becerra-Figueroa, L., Brun, E., Mathieson, M., Farrugia, L. J., Wilson, C. , Prunet, J. and Gamba-Sánchez, D. (2017) Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction. Organic and Biomolecular Chemistry, 15(2), pp. 301-305. (doi: 10.1039/C6OB02333A) (PMID:27897299)

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Abstract

A highly diastereoselective synthesis of trifluoromethylated 1,3-dioxanes is described. The reaction proceeds by an addition/oxa-Michael sequence and works efficiently under mild reaction conditions, with a good substrate scope and acceptable to good yields.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Farrugia, Dr Louis and Wilson, Dr Claire and Mathieson, Mr Michael and Prunet, Dr Joelle
Authors: Becerra-Figueroa, L., Brun, E., Mathieson, M., Farrugia, L. J., Wilson, C., Prunet, J., and Gamba-Sánchez, D.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic and Biomolecular Chemistry
Publisher:Royal Society of Chemistry
ISSN:1477-0520
ISSN (Online):1477-0539
Published Online:23 November 2016
Copyright Holders:Copyright © 2017 The Royal Society of Chemistry
First Published:First published in Organic and Biomolecular Chemistry 15(2):301-305
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
5006132008-12 Doctoral Training GrantMary GoodmanEngineering & Physical Sciences Research Council (EPSRC)EP/P50418X/1VPO VICE PRINCIPAL RESEARCH & ENTERPRISE