Graham, S. and Faizo, A. A. A. (2017) Control of human papillomavirus gene expression by alternative splicing. Virus Research, 231, pp. 83-95. (doi: 10.1016/j.virusres.2016.11.016) (PMID:27867028) (PMCID:PMC5335905)
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Abstract
Human papillomaviruses possess circular double stranded DNA genomes of around 8 kb in size from which multiple mRNAs are synthesized during an infectious life cycle. Although at least three viral promoters are used to initiate transcription, viral mRNAs are largely the product of processing of pre-mRNAs by alternative splicing and polyadenylation. The HPV life cycle and viral gene expression are tightly linked to differentiation of the epithelium the virus infects: there is an orchestrated production of viral mRNAs and proteins. In this review we describe viral mRNA expression and the roles of the SR and hnRNP proteins that respectively positively and negatively regulate splicing. We discuss HPV regulation of splicing factors and detail the evidence that the papillomavirus E2 protein has splicing-related activities. We highlight the possibility that HPV-mediated control of splicing in differentiating epithelial cells may be necessary to accomplish the viral replication cycle.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Graham, Professor Sheila and Faizo, Arwa Ali A |
| Authors: | Graham, S., and Faizo, A. A. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Virus Research |
| Publisher: | Elsevier |
| ISSN: | 0168-1702 |
| ISSN (Online): | 1872-7492 |
| Published Online: | 17 November 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Virus Research 231: 83-95 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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