Drug resistance in eukaryotic microorganisms

Fairlamb, A. H., Gow, N. A.R., Matthews, K. R. and Waters, A. P. (2016) Drug resistance in eukaryotic microorganisms. Nature Microbiology, 1(7), 16092. (doi: 10.1038/nmicrobiol.2016.92) (PMID:27572976) (PMCID:PMC5215055)

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Abstract

Eukaryotic microbial pathogens are major contributors to illness and death globally. Although much of their impact can be controlled by drug therapy as with prokaryotic microorganisms, the emergence of drug resistance has threatened these treatment efforts. Here, we discuss the challenges posed by eukaryotic microbial pathogens and how these are similar to, or differ from, the challenges of prokaryotic antibiotic resistance. The therapies used for several major eukaryotic microorganisms are then detailed, and the mechanisms that they have evolved to overcome these therapies are described. The rapid emergence of resistance and the restricted pipeline of new drug therapies pose considerable risks to global health and are particularly acute in the developing world. Nonetheless, we detail how the integration of new technology, biological understanding, epidemiology and evolutionary analysis can help sustain existing therapies, anticipate the emergence of resistance or optimize the deployment of new therapies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Waters, Professor Andy
Authors: Fairlamb, A. H., Gow, N. A.R., Matthews, K. R., and Waters, A. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Microbiology
Publisher:Nature Publishing Group
ISSN:2058-5276
ISSN (Online):2058-5276
Published Online:24 June 2016
Copyright Holders:Copyright © 2016 Macmillan Publishers Limited
First Published:First published in Nature Microbiology 1: 16092
Publisher Policy:Reproduced in accordance with the publisher copyright policy
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
690321Gene expression in Plasmodium parasites: the molecular mechanics of gametocytogenesis (and variant transcription of genes)Andrew WatersWellcome Trust (WELLCOME)107046/Z/15/ZIII - PARASITOLOGY