Gene × environment interactions in schizophrenia: evidence from genetic mouse models

Moran, P., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J. and O’Tuathaigh, C. (2016) Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2016, 2173748. (doi: 10.1155/2016/2173748) (PMID:27725886) (PMCID:PMC5048038)

Abstract

The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Desbonnet, Dr Lieve and Moran, Mrs Paula
• Authors: Moran, P., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J., and O’Tuathaigh, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience; College of Medical Veterinary and Life Sciences > School of Life Sciences
• Journal Name: Neural Plasticity
• Publisher: Hindawi Publishing Corporation
• ISSN: 2090-5904
• ISSN (Online): 1687-5443
• Copyright Holders: Copyright © 2016 Paul Moran et al.
• First Published: First published in Neural Plasticity 2016: 2173748
• Publisher Policy: Reproduced under a Creative Commons License