Policies on conflicts of interest in health care guideline development: a cross-sectional analysis

Morciano, C., Basevi, V., Faralli, C., Hilton Boon, M. , Tonon, S. and Taruscio, D. (2016) Policies on conflicts of interest in health care guideline development: a cross-sectional analysis. PLoS ONE, 11(11), e0166485. (doi: 10.1371/journal.pone.0166485) (PMID:27846255) (PMCID:PMC5113001)

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Objective: To assess whether organisations that develop health care guidelines have conflict of interest (COI) policies and to review the content of the available COI policies. Methods: Survey and content analysis of COI policies available in English, French, Spanish, and Italian conducted between September 2014 and June 2015. A 24-item data abstraction instrument was created on the basis of guideline development standards. Results: The survey identified 29 organisations from 19 countries that met the inclusion criteria. From these organisations, 19 policies were eligible for inclusion in the content analysis. Over one-third of the policies (7/19, 37%) did not report or did not clearly report whether disclosure was a prerequisite for membership of the guideline panel. Strategies for the prevention of COI such as divestment were mentioned by only two organisations. Only 21% of policies (4/19) used criteria to determine whether an interest constitutes a COI and to assess the severity of the risk imposed. Conclusions: The finding that some organisations, in contradiction of widely available standards, still do not have COI policies publicly available is concerning. Also troubling were the findings that some policies did not clearly report critical steps in obtaining, managing and communicating disclosure of relationships of interest. This in addition to the variability encountered in content and accessibility of COI policies may cause confusion and distrust among guideline users. It is in the interest of guideline users and developers to design an agreed-upon, comprehensive, clear, and accessible COI policy.

Item Type:Articles
Additional Information:Funding: MRC 1517742, Natural experimental approaches to evaluating population health interventions.
Glasgow Author(s) Enlighten ID:Hilton Boon, Dr Michele
Authors: Morciano, C., Basevi, V., Faralli, C., Hilton Boon, M., Tonon, S., and Taruscio, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO SPHSU
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN (Online):1932-6203
Copyright Holders:Copyright © 2016 Morciano et al
First Published:First published in PLoS One 11(11):e0166485
Publisher Policy:Reproduced under a Creative Commons License

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