Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions

Adler, M. J., Jamieson, A. G. and Hamilton, A. D. (2011) Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. In: Vassilev, L. and Fry, D. (eds.) Small-Molecule Inhibitors of Protein-Protein Interactions. Series: Current topics in microbiology and immunology, 348 (348). Springer, pp. 1-23. ISBN 9783642170829 (doi: 10.1007/82_2010_91)

Abstract

Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein–protein interactions. Researchers have recently taken the organizational imitation of protein secondary structure to a new level by using intramolecular hydrogen bonds as stabilizing forces in these small molecule mimetics. The inclusion of these interactions invokes a conformational bias of the system, allowing for greater control of the appearance, and thus often function, of these molecules by design.

• Item Type: Book Sections
• Additional Information: Series ISSN: 0070-217X
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Jamieson, Professor Andrew
• Authors: Adler, M. J., Jamieson, A. G., and Hamilton, A. D.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Current Topics in Microbiology and Immunology
• Publisher: Springer
• ISSN: 0070-217X
• ISBN: 9783642170829

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