A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic

Jamieson, A. G. , Russell, D. and Hamilton, A. D. (2012) A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic. Chemical Communications, 48(31), pp. 3709-3711. (doi: 10.1039/C2CC30295K) (PMID:22399148)

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A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Jamieson, Professor Andrew
Authors: Jamieson, A. G., Russell, D., and Hamilton, A. D.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN (Online):1364-548X
Published Online:17 February 2012

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