Jamieson, A. G. , Russell, D. and Hamilton, A. D. (2012) A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic. Chemical Communications, 48(31), pp. 3709-3711. (doi: 10.1039/C2CC30295K) (PMID:22399148)
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Abstract
A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jamieson, Professor Andrew |
Authors: | Jamieson, A. G., Russell, D., and Hamilton, A. D. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Chemical Communications |
Publisher: | Royal Society of Chemistry |
ISSN: | 1359-7345 |
ISSN (Online): | 1364-548X |
Published Online: | 17 February 2012 |
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