Peptide scanning for studying structure-activity relationships in drug discovery

Jamieson, A. G. , Boutard, N., Sabatino, D. and Lubell, W. D. (2013) Peptide scanning for studying structure-activity relationships in drug discovery. Chemical Biology and Drug Design, 81(1), pp. 148-165. (doi: 10.1111/cbdd.12042) (PMID:23253136)

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Peptide-based therapeutics have grown in importance over the last few decades. Furthermore, peptides have been extensively used as lead compounds in the drug discovery process to investigate the nature of chemical space required for molecular recognition and activity at a variety of targets. This critical commentary reviews scanning techniques, which employ natural and non-proteinogenic amino acids to facilitate understanding of structural requirements for peptide biological activity. The value of sequence analysis by such methods is highlighted by examples, in which the elements for peptide affinity and activity have been elucidated and employed to prepare peptidomimetic leads for drug development.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Jamieson, Professor Andrew
Authors: Jamieson, A. G., Boutard, N., Sabatino, D., and Lubell, W. D.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Biology and Drug Design
Publisher:Wiley, for the American Peptide Society
ISSN (Online):1747-0285
Published Online:17 December 2012

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