TGF-β in tolerance, development and regulation of immunity

Johnston, C. J.C., Smyth, D. J. , Dresser, D. W. and Maizels, R. M. (2016) TGF-β in tolerance, development and regulation of immunity. Cellular Immunology, 299, pp. 14-22. (doi: 10.1016/j.cellimm.2015.10.006) (PMID:26617281) (PMCID:PMC4711336)

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Abstract

The TGF-β superfamily is an ancient metazoan protein class which cuts across cell and tissue differentiation, developmental biology and immunology. Its many members are regulated at multiple levels from intricate control of gene transcription, post-translational processing and activation, and signaling through overlapping receptor structures and downstream intracellular messengers. We have been interested in TGF-β homologues firstly as key players in the induction of immunological tolerance, the topic so closely associated with Ray Owen. Secondly, our interests in how parasites may manipulate the immune system of their host has also brought us to study the TGF-β pathway in infections with longlived, essentially tolerogenic, helminth parasites. Finally, within the spectrum of mammalian TGF-β proteins is an exquisitely tightly-regulated gene, anti-Müllerian hormone (AMH), whose role in sex determination underpins the phenotype of freemartin calves that formed the focus of Ray’s seminal work on immunological tolerance.

Item Type:Articles
Additional Information:The authors gratefully acknowledge funding from the Rainin Foundation (Ref 13-H6), and the Wellcome Trust, through a Senior Investigator Award (Ref 106122) and a studentship to CJCJ through the Edinburgh Clinical Academic Track (Ref 100555).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smyth, Dr Danielle and Maizels, Professor Rick
Authors: Johnston, C. J.C., Smyth, D. J., Dresser, D. W., and Maizels, R. M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Cellular Immunology
Publisher:Elsevier
ISSN:0008-8749
Published Online:23 November 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Cellular Immunology 299: 14-22
Publisher Policy:Reproduced under a Creative Commons License

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