Gause, W. C. and Maizels, R. M. (2016) Macrobiota — helminths as active participants and partners of the microbiota in host intestinal homeostasis. Current Opinion in Microbiology, 32, pp. 14-18. (doi: 10.1016/j.mib.2016.04.004) (PMID:27116368) (PMCID:PMC4983462)
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Abstract
Important insights have recently been gained in our understanding of the intricate relationship in the intestinal milieu between the vertebrate host mucosal immune response, commensal bacteria, and helminths. Helminths are metazoan worms (macrobiota) and trigger immune responses that include potent regulatory components capable of controlling harmful inflammation, protecting barrier function and mitigating tissue damage. They can secrete a variety of products that directly affect immune regulatory function but they also have the capacity to influence the composition of microbiota, which can also then impact immune function. Conversely, changes in microbiota can affect susceptibility to helminth infection, indicating that crosstalk between these two disparate groups of endobiota can play an essential role in host intestinal immune function and homeostasis.
Item Type: | Articles |
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Additional Information: | WCG is supported by grants from the Amelior Foundation and the National Institutes of Health (1R01AI107588). RMM is supported by grants from the Rainin Foundation (Ref. 12-H4) and the Wellcome Trust (Ref. 106122). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
Authors: | Gause, W. C., and Maizels, R. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Current Opinion in Microbiology |
Publisher: | Elsevier |
ISSN: | 1369-5274 |
Published Online: | 23 April 2016 |
Copyright Holders: | Copyright © 2016 Elsevier Ltd. |
First Published: | First published in Current Opinion in Microbiology 32: 14-18 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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