A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination

Goebbels, S. et al. (2017) A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), pp. 10-15. (doi: 10.1038/nn.4425) (PMID:27775720)

Abstract

The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1–mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger all steps of myelination.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Edgar, Professor Julia
• Authors: Goebbels, S., Wieser, G. L., Pieper, A., Spitzer, S., Weege, B., Yan, K., Edgar, J. M., Yagensky, O., Wichert, S. P., Agarwal, A., Karram, K., Renier, N., Tessier-Lavigne, M., Rossner, M. J., Káradóttir, R. T., and Nave, K.-A.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Nature Neuroscience
• Publisher: Nature Publishing Group
• ISSN: 1097-6256
• ISSN (Online): 1546-1726
• Published Online: 24 October 2016
• Copyright Holders: Copyright © 2016 Nature Publishing Group
• First Published: First published in Nature Neuroscience 20(1):10-15
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher