A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination

Goebbels, S. et al. (2017) A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), pp. 10-15. (doi: 10.1038/nn.4425) (PMID:27775720)

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The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1–mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger all steps of myelination.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Edgar, Professor Julia
Authors: Goebbels, S., Wieser, G. L., Pieper, A., Spitzer, S., Weege, B., Yan, K., Edgar, J. M., Yagensky, O., Wichert, S. P., Agarwal, A., Karram, K., Renier, N., Tessier-Lavigne, M., Rossner, M. J., Káradóttir, R. T., and Nave, K.-A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Nature Neuroscience
Publisher:Nature Publishing Group
ISSN (Online):1546-1726
Published Online:24 October 2016
Copyright Holders:Copyright © 2016 Nature Publishing Group
First Published:First published in Nature Neuroscience 20(1):10-15
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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