Yanguas, S. C., Willebrords, J., Johnstone, S. R., Maes, M., Decrock, E., De Bock, M., Leybaert, L., Cogliati, B. and Vinken, M. (2017) Pannexin1 as mediator of inflammation and cell death. Biochimica et Biophysica Acta: Molecular Cell Research, 1864(1), pp. 51-61. (doi: 10.1016/j.bbamcr.2016.10.006) (PMID:27741412)
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Abstract
Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Furthermore, these cellular pores facilitate cell death, including apoptosis, pyroptosis and autophagy. The present paper reviews the roles of pannexin channels in inflammation and cell death. In a first part, a state-of-the-art overview of pannexin channel structure, regulation and function is provided. In a second part, the mechanisms behind their involvement in inflammation and cell death are discussed.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was funded by grants of the European Research Council (starting grant 335476), the Fund for Scientific Research-Flanders (FWO grants G009514N and G010214N), the University Hospital of the Vrije Universiteit Brussel-Belgium (“Willy Gepts Fonds” UZ-VUB), the University of São Paulo-Brazil and the São Paulo Research Foundation-Brazil (FAPESP SPEC grant 2013/50420-6). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Johnstone, Dr Scott |
| Authors: | Yanguas, S. C., Willebrords, J., Johnstone, S. R., Maes, M., Decrock, E., De Bock, M., Leybaert, L., Cogliati, B., and Vinken, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Biochimica et Biophysica Acta: Molecular Cell Research |
| Publisher: | Elsevier |
| ISSN: | 0167-4889 |
| ISSN (Online): | 1879-2596 |
| Published Online: | 11 October 2016 |
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